产品
编 号：F416627
分子式：C8H7NO2S
分子量：181.21
分子式：C8H7NO2S
分子量：181.21
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
704
In-stock
5mg
400
In-stock
10mg
640
In-stock
结构图
CAS No: 64984-31-2
产品详情
生物活性：
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
体内研究：
Pifithrin-μ (40 mg/kg, i.p.) shows no protective effect against doses of radiation that cause gastrointestinal syndrome in mice. Pifithrin-μ (PES, 10 mg/kg) shows antitumor effect in mice bearing A549 cells. Pifithrin-μ exhibits neuroprotective effect with the P53-inhibitor pifithrin-μ after cardiac arrest in a rodent model.
体外研究：
Pifithrin-μ (10 μM) is a p53 inhibitor, which inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation, activity of caspases 2, 8, 9 and 10 in a cell-free system, or NF-κB-dependent transcription. Pifithrin-μ (PES) time- and dose-dependently reduces viability in A549 cells, with IC50s of 44.9 and 25.7 μM at 24 h and 48 h. Pifithrin-μ (20 μM) suppresses the cell migration, induces cell cycle arrest and cell apoptosis in A549 and H460 cells. Pifithrin-μ (10 or 20 μM) inhibits activities of AKT, ERK, and Hsp70 in A549 and H460 cells. Pifithrin-μ (20 μM) sensitizes A549 and H460 cell lines to TRAIL-induced cell proliferation inhibition and apoptosis.
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
体内研究：
Pifithrin-μ (40 mg/kg, i.p.) shows no protective effect against doses of radiation that cause gastrointestinal syndrome in mice. Pifithrin-μ (PES, 10 mg/kg) shows antitumor effect in mice bearing A549 cells. Pifithrin-μ exhibits neuroprotective effect with the P53-inhibitor pifithrin-μ after cardiac arrest in a rodent model.
体外研究：
Pifithrin-μ (10 μM) is a p53 inhibitor, which inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation, activity of caspases 2, 8, 9 and 10 in a cell-free system, or NF-κB-dependent transcription. Pifithrin-μ (PES) time- and dose-dependently reduces viability in A549 cells, with IC50s of 44.9 and 25.7 μM at 24 h and 48 h. Pifithrin-μ (20 μM) suppresses the cell migration, induces cell cycle arrest and cell apoptosis in A549 and H460 cells. Pifithrin-μ (10 or 20 μM) inhibits activities of AKT, ERK, and Hsp70 in A549 and H460 cells. Pifithrin-μ (20 μM) sensitizes A549 and H460 cell lines to TRAIL-induced cell proliferation inhibition and apoptosis.
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