产品
编 号:F417382
分子式:C6H10O4
分子量:146.14
产品类型
结构图
CAS No: 652-67-5
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产品详情
生物活性:
Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic.
体内研究:
Isosorbide (5 mg/kg; a single p.o.) significantly increases the urine volume of rats within 2 hours which lasts through the 8 hour experimental period.Isosorbide (5 mg/kg; a single p.o. 30 min prior to gallium injection) significantly reduces the urinary concentrations of both gallium and calcium in rats.Isosorbide (5 mg/kg; p.o. 30 min prior to gallium injection for 6 d) results in the formation of fewer renal precipitates and histopathologic changes than in the nondiuresed animals.