产品
编 号：F417893
分子式：C42H66O16
分子量：826.96
分子式：C42H66O16
分子量：826.96
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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20mg
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结构图
CAS No: 65497-07-6
产品详情
生物活性：
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta.Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models, has selective inhibitory activity towards cyclooxygenase-2 (COX-2).Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways.
体内研究：
EscuLentoside A (EsA) (腹膜内注射；20 mg/kg；每天一次；4 周) 通过调节炎性细胞因子、抑制肾细胞增殖和诱导细胞凋亡在 BXSB 小鼠的处理中发挥重要作用。 EscuLentoside A (EsA) (腹膜内注射；5、10 和 20 mg/kg；每天一次；7 天) 剂量依赖性地降低 TNF、IL-1 和 IL-6 水平在 LPS 攻击后的小鼠血清中。Animal Model: BXSB mice
Dosage:20 mg/kg
Administration:Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks
Result: Alleviated the renal damage of LN.
体外研究：
EscuLentoside A (0-10 μM；24 小时) 降低了致敏巨噬细胞中 TNF 浓度的释放。
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta.Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models, has selective inhibitory activity towards cyclooxygenase-2 (COX-2).Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways.
体内研究：
EscuLentoside A (EsA) (腹膜内注射；20 mg/kg；每天一次；4 周) 通过调节炎性细胞因子、抑制肾细胞增殖和诱导细胞凋亡在 BXSB 小鼠的处理中发挥重要作用。 EscuLentoside A (EsA) (腹膜内注射；5、10 和 20 mg/kg；每天一次；7 天) 剂量依赖性地降低 TNF、IL-1 和 IL-6 水平在 LPS 攻击后的小鼠血清中。Animal Model: BXSB mice
Dosage:20 mg/kg
Administration:Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks
Result: Alleviated the renal damage of LN.
体外研究：
EscuLentoside A (0-10 μM；24 小时) 降低了致敏巨噬细胞中 TNF 浓度的释放。
产品资料
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