产品
编 号：F420133
分子式：C23H14Na2O6
分子量：432.33
分子式：C23H14Na2O6
分子量：432.33
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
10g
280
In-stock
25g
560
In-stock
结构图
CAS No: 6640-22-8
产品详情
生物活性：
Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect.
体内研究：
Pamoic acid disodium (0-100 mg/kg；sc；一次) 在腹部收缩试验中诱导剂量相关的抗伤害作用。Animal Model:Swiss-Webster mice (30–35 g)
Dosage:25, 50, and 100 mg/kg
Administration:Subcutaneous injection, once
Result:Elicited dose-related antinociception, the dose causing 50% antinociception being 40.5 mg/kg.
体外研究：
Pamoic acid (0.1 nM-0.1 mM) 诱导 GPR35a 内化，EC50 值为 22 nM。 Pamoic acid (0-10 μM) 诱导 ERK1/2 激活。
Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect.
体内研究：
Pamoic acid disodium (0-100 mg/kg；sc；一次) 在腹部收缩试验中诱导剂量相关的抗伤害作用。Animal Model:Swiss-Webster mice (30–35 g)
Dosage:25, 50, and 100 mg/kg
Administration:Subcutaneous injection, once
Result:Elicited dose-related antinociception, the dose causing 50% antinociception being 40.5 mg/kg.
体外研究：
Pamoic acid (0.1 nM-0.1 mM) 诱导 GPR35a 内化，EC50 值为 22 nM。 Pamoic acid (0-10 μM) 诱导 ERK1/2 激活。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备