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编 号：F422864
分子式：C28H32F2N2O
分子量：450.56
分子式：C28H32F2N2O
分子量：450.56
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CAS No: 67469-69-6
产品详情
生物活性：
Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT).
体内研究：
Vanoxerine (GBR-12909) (2.5-20 mg/kg; i.p.) significantly increases the ambulatory activity.Animal Model:Male mice(ddY strain at 6 weeks of age)
Dosage:2.5, 5, 10, 20 mg/kg
Administration:Intraperitoneal injection
Result:The ambulatory activity of mice increased in a dose-dependent manner, with a maximal increase at 30 min after the administration.
体外研究：
Vanoxerine (GBR-12909) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT. Vanoxerine (GBR-12909) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity.
Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT).
体内研究：
Vanoxerine (GBR-12909) (2.5-20 mg/kg; i.p.) significantly increases the ambulatory activity.Animal Model:Male mice(ddY strain at 6 weeks of age)
Dosage:2.5, 5, 10, 20 mg/kg
Administration:Intraperitoneal injection
Result:The ambulatory activity of mice increased in a dose-dependent manner, with a maximal increase at 30 min after the administration.
体外研究：
Vanoxerine (GBR-12909) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT. Vanoxerine (GBR-12909) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity.
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