产品
编 号：F422867
分子式：C28H34Cl2F2N2O
分子量：523.49
分子式：C28H34Cl2F2N2O
分子量：523.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
224
In-stock
10mg
320
In-stock
50mg
792
In-stock
结构图
CAS No: 67469-78-7
产品详情
生物活性：
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT).
体内研究：
Vanoxerine dihydrochloride (2.5-20 mg/kg；腹腔注射) 显著增加行走活动。Animal Model:Male mice (ddY strain at 6 weeks of age)
Dosage:2.5, 5, 10, 20 mg/kg
Administration:Intraperitoneal injection
Result:The ambulatory activity of mice increased in a dose-dependent manner, with a maximal increase at 30 min after the administration.
体外研究：
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 抑制多巴胺(DA)的摄取，在 IC50 低纳摩尔范围内，并且作为去甲肾上腺素和5-羟色胺摄取抑制剂的效力低几倍。Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 也是一种口服的混合离子通道阻滞剂，具有 IKr、INa 和 L 型钙通道活性。
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT).
体内研究：
Vanoxerine dihydrochloride (2.5-20 mg/kg；腹腔注射) 显著增加行走活动。Animal Model:Male mice (ddY strain at 6 weeks of age)
Dosage:2.5, 5, 10, 20 mg/kg
Administration:Intraperitoneal injection
Result:The ambulatory activity of mice increased in a dose-dependent manner, with a maximal increase at 30 min after the administration.
体外研究：
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 抑制多巴胺(DA)的摄取，在 IC50 低纳摩尔范围内，并且作为去甲肾上腺素和5-羟色胺摄取抑制剂的效力低几倍。Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 也是一种口服的混合离子通道阻滞剂，具有 IKr、INa 和 L 型钙通道活性。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备