产品
编 号:F424375
分子式:C11H14ClN3O5
分子量:303.7
产品类型
结构图
CAS No: 67953-08-6
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产品详情
生物活性:
GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells.
体外研究:
GPNA (10-1000 μM; 48?hours) induces a dose-dependent decrease of cell viability in A549 cells.