产品
编 号：F424427
分子式：C17H14O7
分子量：330.29
分子式：C17H14O7
分子量：330.29
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
20mg
询价
询价
结构图
CAS No: 67979-25-3
产品详情
生物活性：
Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation.
体内研究：
Aurantio-obtusin (5-15 mg/kg; 口服; 单剂量) 在 HFSW 诱导的小鼠中能够以剂量依赖的方式减少 HFSW 引起的脂滴积聚和广泛的脂肪变性。Aurantio-obtusin (5-15 mg/kg; 口服; 单剂量) 在 HFSW 诱导的小鼠中抑制脂肪酸合成，促进 FAO 激活 AMPK 信号和自噬。Animal Model:C57BL/6J mice model
Dosage:5 mg/kg, 10 mg/kg, 15 mg/kg
Administration:Oral gavage (p.o.), feeding with HFSW diet for 4 weeks then giving different dose of Aurantio-obtusin for another 4 weeks.
Result:Decreased the levels of TG and TC in liver and TG, ALT and AST in serum induced by HSFW.Reduced the number and size of fat droplets in liver cells.Significantly increased AMPK phosphorylation in HFSW-induced mice.
体外研究：
Aurantio-obtusin (6.25-100 μM; 24 h) 在 LPS (0.2 μg/mL) 处理的 RAW264.7 的细胞中能够显著降低 NO、PGE2 的生成，显著抑制 IL-6 、TNF-α 和 COX-2 蛋白的表达。Aurantio-obtusin (6.25-100 μM; 12 h) 在 LPS (0.2 μg/mL) 处理的 RAW264.7 的细胞中通过抑制 i-κB 和 IKK 磷酸化来抑制 NF-κB 活化。Aurantioobtusin (1-10000 nM) 以浓度依赖的方式诱导大鼠 MA 小阻力血管舒张。
Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation.
体内研究：
Aurantio-obtusin (5-15 mg/kg; 口服; 单剂量) 在 HFSW 诱导的小鼠中能够以剂量依赖的方式减少 HFSW 引起的脂滴积聚和广泛的脂肪变性。Aurantio-obtusin (5-15 mg/kg; 口服; 单剂量) 在 HFSW 诱导的小鼠中抑制脂肪酸合成，促进 FAO 激活 AMPK 信号和自噬。Animal Model:C57BL/6J mice model
Dosage:5 mg/kg, 10 mg/kg, 15 mg/kg
Administration:Oral gavage (p.o.), feeding with HFSW diet for 4 weeks then giving different dose of Aurantio-obtusin for another 4 weeks.
Result:Decreased the levels of TG and TC in liver and TG, ALT and AST in serum induced by HSFW.Reduced the number and size of fat droplets in liver cells.Significantly increased AMPK phosphorylation in HFSW-induced mice.
体外研究：
Aurantio-obtusin (6.25-100 μM; 24 h) 在 LPS (0.2 μg/mL) 处理的 RAW264.7 的细胞中能够显著降低 NO、PGE2 的生成，显著抑制 IL-6 、TNF-α 和 COX-2 蛋白的表达。Aurantio-obtusin (6.25-100 μM; 12 h) 在 LPS (0.2 μg/mL) 处理的 RAW264.7 的细胞中通过抑制 i-κB 和 IKK 磷酸化来抑制 NF-κB 活化。Aurantioobtusin (1-10000 nM) 以浓度依赖的方式诱导大鼠 MA 小阻力血管舒张。
产品资料
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