产品
编 号：F428572
分子式：C11H14N4O4
分子量：266.25
分子式：C11H14N4O4
分子量：266.25
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
218
In-stock
5mg
480
In-stock
10mg
720
In-stock
50mg
2000
In-stock
100mg
2960
In-stock
结构图
CAS No: 69-33-0
产品详情
生物活性：
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP. Tubercidin has antiviral activity.
体内研究：
Tubercidin (7-Deazaadenosine) (腹膜内注射；5 mg/kg；10 天) 与 NBMPR-P 合作保护小鼠免受 Tubercidin 的致死性，并允许第二次重复该方案，存活率为 100%。Animal Model:Female CD1 mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg; 10 days
Result:Protectedthe mice from the lethality of tubercidin.
体外研究：
Tubercidin (7-Deazaadenosine) (0-10 nM；14 d) 对骨髓和红系人骨髓祖细胞具有剂量依赖性抑制作用，Tubercidin 对 CFU-GM 和 BFU-E 细胞的 IC50 分别为 3.4 nM 和 3.7 nM。
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP. Tubercidin has antiviral activity.
体内研究：
Tubercidin (7-Deazaadenosine) (腹膜内注射；5 mg/kg；10 天) 与 NBMPR-P 合作保护小鼠免受 Tubercidin 的致死性，并允许第二次重复该方案，存活率为 100%。Animal Model:Female CD1 mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg; 10 days
Result:Protectedthe mice from the lethality of tubercidin.
体外研究：
Tubercidin (7-Deazaadenosine) (0-10 nM；14 d) 对骨髓和红系人骨髓祖细胞具有剂量依赖性抑制作用，Tubercidin 对 CFU-GM 和 BFU-E 细胞的 IC50 分别为 3.4 nM 和 3.7 nM。
产品资料
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