产品
编 号：F433293
分子式：C17H15ClF3NO2
分子量：357.75
分子式：C17H15ClF3NO2
分子量：357.75
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 709676-56-2
产品详情
生物活性：
TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory.CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP). CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function. CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model.
体内研究：
CSP-TTK21 ( 20 mg/kg; i.p.单剂量) 有可能增强神经发生和大脑功能。CSP-TTK21 (20 mg/kg; p.o; 单剂量) 的长期增效与腹腔注射相当，表明野生型老鼠的记忆有效增强。CSP-TTK21 (10 mg/kg; p.o; 每周一次) 在脊髓损伤的老鼠中促进脊髓损伤后的运动恢复，和促进脊髓损伤后前额叶皮层和小脑的再生相关基因的表达。Animal Model:B57BL/6J male
Dosage:CSP-TTK21; 20 mg/kg; single dose
Administration:i.p.
Result:Increased histone acetylation significantly in the hippocampus and frontal cortex. CSP-TTK21 crossed the blood-brain barrier and was primarily detected in the brain, liver, and spleen. It promoted differentiation of newly generated neurons in the dentate gyrus.Mice with CSP-TTK21 displayed a persistent memory of the platform location in a Morris water maze task for a longer period compared to controls, demonstrating enhanced long-term memory.
Animal Model:Wild-type mice
Dosage:CSP-TTK21; 20 mg/kg; single dose
Administration:p.o.
Result:The administered compound crossed the blood-brain barrier, induced histone acetylation specifically H4K12ac and H3K14ac marks in the hippocampus, and did not alter basal synaptic transmission. It was found to enhance long-term potentiation comparably to intraperitoneal injection, suggesting effective memory enhancement through oral delivery.
Animal Model:rats with spinal cord injury
Dosage:CSP-TTK21; 10 mg/kg; weekly
Administration:p.o.
Result:Rats with CSP-TTK21 showed significant improvement in locomotion and rearing activity compared to controls. Histone acetylation was notably increased in the spinal cord, suggesting enhanced gene expression linked to regeneration and functional recovery.Enhanced histone acetylation levels (H4K12ac, H3K27ac, H3K9ac) were observed in the prefrontal cortex and cerebellum of rats with CSP-TTK21, indicating active epigenetic modifications that support neuronal regeneration and functional recovery.
体外研究：
TTK21 (50-275 μM) 能够浓度依赖性地激活 CBP 和 p300 乙酰转移酶，提高组蛋白的乙酰化水平。有效地激活了 CBP/p300 的活性，并且增加了组蛋白 H3 和 H4 的乙酰化。100 μM TTK21 显著促进了 p300 的自乙酰化。TTK21 (50-275 μM; 6-24 h) 在 Hela 细胞中，本身不能有效穿透细胞膜进入细胞。但当与碳纳米球 CSP 结合后，能够进入 SH-SY5Y 神经细胞并显著提高组蛋白 H3 的乙酰化水平，表明 CSP-TTK21 复合物具有穿透细胞膜的能力。CSP-TTK21 (0.36 μg/mL; 1 h) 恢复了由 Aβ (1–42) 多聚体引起的蛋白质合成依赖的 long-term potentiation (LTP) 损伤。
TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory.CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP). CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function. CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model.
体内研究：
CSP-TTK21 ( 20 mg/kg; i.p.单剂量) 有可能增强神经发生和大脑功能。CSP-TTK21 (20 mg/kg; p.o; 单剂量) 的长期增效与腹腔注射相当，表明野生型老鼠的记忆有效增强。CSP-TTK21 (10 mg/kg; p.o; 每周一次) 在脊髓损伤的老鼠中促进脊髓损伤后的运动恢复，和促进脊髓损伤后前额叶皮层和小脑的再生相关基因的表达。Animal Model:B57BL/6J male
Dosage:CSP-TTK21; 20 mg/kg; single dose
Administration:i.p.
Result:Increased histone acetylation significantly in the hippocampus and frontal cortex. CSP-TTK21 crossed the blood-brain barrier and was primarily detected in the brain, liver, and spleen. It promoted differentiation of newly generated neurons in the dentate gyrus.Mice with CSP-TTK21 displayed a persistent memory of the platform location in a Morris water maze task for a longer period compared to controls, demonstrating enhanced long-term memory.
Animal Model:Wild-type mice
Dosage:CSP-TTK21; 20 mg/kg; single dose
Administration:p.o.
Result:The administered compound crossed the blood-brain barrier, induced histone acetylation specifically H4K12ac and H3K14ac marks in the hippocampus, and did not alter basal synaptic transmission. It was found to enhance long-term potentiation comparably to intraperitoneal injection, suggesting effective memory enhancement through oral delivery.
Animal Model:rats with spinal cord injury
Dosage:CSP-TTK21; 10 mg/kg; weekly
Administration:p.o.
Result:Rats with CSP-TTK21 showed significant improvement in locomotion and rearing activity compared to controls. Histone acetylation was notably increased in the spinal cord, suggesting enhanced gene expression linked to regeneration and functional recovery.Enhanced histone acetylation levels (H4K12ac, H3K27ac, H3K9ac) were observed in the prefrontal cortex and cerebellum of rats with CSP-TTK21, indicating active epigenetic modifications that support neuronal regeneration and functional recovery.
体外研究：
TTK21 (50-275 μM) 能够浓度依赖性地激活 CBP 和 p300 乙酰转移酶，提高组蛋白的乙酰化水平。有效地激活了 CBP/p300 的活性，并且增加了组蛋白 H3 和 H4 的乙酰化。100 μM TTK21 显著促进了 p300 的自乙酰化。TTK21 (50-275 μM; 6-24 h) 在 Hela 细胞中，本身不能有效穿透细胞膜进入细胞。但当与碳纳米球 CSP 结合后，能够进入 SH-SY5Y 神经细胞并显著提高组蛋白 H3 的乙酰化水平，表明 CSP-TTK21 复合物具有穿透细胞膜的能力。CSP-TTK21 (0.36 μg/mL; 1 h) 恢复了由 Aβ (1–42) 多聚体引起的蛋白质合成依赖的 long-term potentiation (LTP) 损伤。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备