产品
编 号：F433751
分子式：C19H22O2
分子量：282.38
分子式：C19H22O2
分子量：282.38
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规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 71109-09-6
产品详情
生物活性：
Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM.
体内研究：
Pharmacokinetic parameters of vedaprofen in dogs.Intravenous dose (mg/kg)t1/2β (h)AUC0–48 h (h·ng/mL)AUC0–∞ (h·ng/mL)
0.516.8±2.28612±11359518±1223
Oral dose (mg/kg)t1/2β (h)Cmax (ng/mL)tmax (h)AUC0–48 h (h·ng/mL)AUC0–∞ (h·ng/mL)F0–∞ (%)
0.512.7±2.12739±2770.63±0.147090±13117650±134886±7
体外研究：
Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9±5 and 630±148 ng/mL, respectively.Vedaprofen inhibit the E. coli DNA polymerase III β subunit with antibacterial potency.Vedaprofen shows high E. coli SC binding affinity (Ki=131 μM).
Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM.
体内研究：
Pharmacokinetic parameters of vedaprofen in dogs.Intravenous dose (mg/kg)t1/2β (h)AUC0–48 h (h·ng/mL)AUC0–∞ (h·ng/mL)
0.516.8±2.28612±11359518±1223
Oral dose (mg/kg)t1/2β (h)Cmax (ng/mL)tmax (h)AUC0–48 h (h·ng/mL)AUC0–∞ (h·ng/mL)F0–∞ (%)
0.512.7±2.12739±2770.63±0.147090±13117650±134886±7
体外研究：
Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9±5 and 630±148 ng/mL, respectively.Vedaprofen inhibit the E. coli DNA polymerase III β subunit with antibacterial potency.Vedaprofen shows high E. coli SC binding affinity (Ki=131 μM).
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