产品
编 号：F434019
分子式：C22H21N3O3S
分子量：407.49
分子式：C22H21N3O3S
分子量：407.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 71203-35-5
产品详情
生物活性：
ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines.
体内研究：
ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice.Animal Model:C57Bl/6J mice
Dosage:10 μM
Administration:Intracerebroventricular injection
Result:Increased anxiety in mice.
体外研究：
ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively. ML141 inhibits 3T3 fibroblast filopodia formation and inhibits ovarian cancer cell migration.
ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines.
体内研究：
ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice.Animal Model:C57Bl/6J mice
Dosage:10 μM
Administration:Intracerebroventricular injection
Result:Increased anxiety in mice.
体外研究：
ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively. ML141 inhibits 3T3 fibroblast filopodia formation and inhibits ovarian cancer cell migration.
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