产品
编 号：F434200
分子式：C36H62N4
分子量：550.9
分子式：C36H62N4
分子量：550.9
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CAS No: 71251-02-0
产品详情
生物活性：
Octenidine is a potent antibacterial agent, possessing activity against multidrug-resistant Gram-negative pathogens. Octenidine can inhibit the expression of biofilm genes and destroy the formation of biofilms.
体内研究：
Octenidine reduces bacterial counts on mice wounds and inhibit meticillin-resistant Staphylococcus aureus (MRSA).Animal Model:Mice (a six-millimetre punch full-thickness wound was inoculated with MRSA suspension)
Dosage:
Administration:Administrated once 24 hours post-wounding
Result:Accelerated healing and reduced by >3.6 log cfu/g bacterial counts on the wounds relative to the PBS-treated control.Exhibited lower burden of the inflammatory cells, more mature collagen fibres and well-defined epithelialisation.Inhibited the expression of MRSA and its biofilm genes by nearly 100%.
体外研究：
Octenidine has antimicrobial activity against multidrug-resistant Gram-negative pathogens.Escherichia coli Pseudomonas aeruginosa
WTCTX-M-1CTX-M-15NDM-1VIM-15WTPER-1VEB-1OprDVIM-2
MIC (mg/L)0.52.51.252.51040404040
Octenidine (0-20 h) retardants P. aeruginosa growth in prolonged exposure condition.
Octenidine is a potent antibacterial agent, possessing activity against multidrug-resistant Gram-negative pathogens. Octenidine can inhibit the expression of biofilm genes and destroy the formation of biofilms.
体内研究：
Octenidine reduces bacterial counts on mice wounds and inhibit meticillin-resistant Staphylococcus aureus (MRSA).Animal Model:Mice (a six-millimetre punch full-thickness wound was inoculated with MRSA suspension)
Dosage:
Administration:Administrated once 24 hours post-wounding
Result:Accelerated healing and reduced by >3.6 log cfu/g bacterial counts on the wounds relative to the PBS-treated control.Exhibited lower burden of the inflammatory cells, more mature collagen fibres and well-defined epithelialisation.Inhibited the expression of MRSA and its biofilm genes by nearly 100%.
体外研究：
Octenidine has antimicrobial activity against multidrug-resistant Gram-negative pathogens.Escherichia coli Pseudomonas aeruginosa
WTCTX-M-1CTX-M-15NDM-1VIM-15WTPER-1VEB-1OprDVIM-2
MIC (mg/L)0.52.51.252.51040404040
Octenidine (0-20 h) retardants P. aeruginosa growth in prolonged exposure condition.
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