产品
编 号：F435462
分子式：C41H64O13
分子量：764.94
分子式：C41H64O13
分子量：764.94
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
400
In-stock
10mg
640
In-stock
50mg
1920
In-stock
100mg
2880
In-stock
结构图
CAS No: 71-63-6
产品详情
生物活性：
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .
体内研究：
Digitoxin (1-2 mg/kg, Intraperitoneal injection, once a day for 19 days) 在裸鼠中具有抗癌作用。Digitoxin (0.3-3 μg/kg, Intraperitoneal injection, once a day for 4 days) 阻断棉花鼠肺内宿主细胞因子的过度产生。Animal Model:nude mice harboring HeLa tumor xenografts
Dosage:1 mg/kg, 2 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Decreased the tumor volume from 330.71±45.61 to 214.56.93±73.25 mm.Strongly increased the protein levels of cleaved caspase-3.Reduced the number of Ki-67-positive cells.
Animal Model:cotton rats
Dosage:0.3 μg/kg, 1 μg/kg, 3 μg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Blocked cytokine storm.Differentially affected cytokine expression.Left immune cell density intact in virus-infected lung.
体外研究：
Digitoxin (0-80 nM, 72 h) 降低 PC12 细胞的存活率。Digitoxin (4-1000 nM, 24-48 h) 在 MHCC97H, A549, HCT116 和 HeLa 细胞中具有抗肿瘤作用。Digitoxin (4-100 nM, 24-48 h) 干扰 HeLa 细胞的细胞周期。Digitoxin (20-500 nM, 48 h) 激活 HeLa 细胞线粒体凋亡。
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .
体内研究：
Digitoxin (1-2 mg/kg, Intraperitoneal injection, once a day for 19 days) 在裸鼠中具有抗癌作用。Digitoxin (0.3-3 μg/kg, Intraperitoneal injection, once a day for 4 days) 阻断棉花鼠肺内宿主细胞因子的过度产生。Animal Model:nude mice harboring HeLa tumor xenografts
Dosage:1 mg/kg, 2 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Decreased the tumor volume from 330.71±45.61 to 214.56.93±73.25 mm.Strongly increased the protein levels of cleaved caspase-3.Reduced the number of Ki-67-positive cells.
Animal Model:cotton rats
Dosage:0.3 μg/kg, 1 μg/kg, 3 μg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Blocked cytokine storm.Differentially affected cytokine expression.Left immune cell density intact in virus-infected lung.
体外研究：
Digitoxin (0-80 nM, 72 h) 降低 PC12 细胞的存活率。Digitoxin (4-1000 nM, 24-48 h) 在 MHCC97H, A549, HCT116 和 HeLa 细胞中具有抗肿瘤作用。Digitoxin (4-100 nM, 24-48 h) 干扰 HeLa 细胞的细胞周期。Digitoxin (20-500 nM, 48 h) 激活 HeLa 细胞线粒体凋亡。
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