产品
编 号：F436263
分子式：C41H66O12
分子量：750.96
分子式：C41H66O12
分子量：750.96
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CAS No: 7182-54-9
产品详情
生物活性：
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity.
体内研究：
Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria.
体外研究：
Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM).Monactin inhibits TCF/β-catenin transcriptional activity.At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+).
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity.
体内研究：
Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria.
体外研究：
Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM).Monactin inhibits TCF/β-catenin transcriptional activity.At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+).
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