产品
编 号：F052223
分子式：C12H11NO6
分子量：265.22
分子式：C12H11NO6
分子量：265.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
640
In-stock
10mg
1040
In-stock
结构图
CAS No: 116313-94-1
产品详情
生物活性：
Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation.
体内研究：
Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats.Animal Model:Eighty-six male Wistar rats, weighing 140-350 g.
Dosage:30 mg/kg (3.3 mL/kg).
Administration:IP, once daily for 13 days.
Result:Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h.Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia.Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats.
体外研究：
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.
Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation.
体内研究：
Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats.Animal Model:Eighty-six male Wistar rats, weighing 140-350 g.
Dosage:30 mg/kg (3.3 mL/kg).
Administration:IP, once daily for 13 days.
Result:Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h.Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia.Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats.
体外研究：
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.
产品资料
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