产品
编 号：F438895
分子式：C11H11N3S
分子量：217.29
分子式：C11H11N3S
分子量：217.29
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 72596-74-8
产品详情
生物活性：
PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro.
体外研究：
PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs.PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity.PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM.PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora.
PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro.
体外研究：
PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs.PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity.PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM.PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora.
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