产品
编 号：F439207
分子式：C19H21N
分子量：263.38
分子式：C19H21N
分子量：263.38
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规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 72-69-5
产品详情
生物活性：
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects.N
体内研究：
Nortriptyline（10-20 mg/kg；腹腔注射；每天；持续三周）可抑制接种 MBT-2 细胞的小鼠膀胱肿瘤的生长。Animal Model:Adult male C3H/HeN mice (25-30 g; 2-3 months of age) injected with MBT-2 cells
Dosage:10 or 20 mg/kg
Administration:Intraperitoneal injection; every day; for three weeks.
Result:Suppressed tumor growth in mice inoculated with MBT-2 cells.
体外研究：
Amitriptyline 由 CYP2C19 代谢为活性代谢物 Nortriptyline。Nortriptyline 比血清素更能有效地阻止去甲肾上腺素的再摄取。Nortriptyline（6.25-100 μM；24-72 小时）以浓度和时间依赖性方式显着降低 TCCSUP 和小鼠 MBT-2 膀胱癌细胞的活力。Nortriptyline（12.55-100 μM；24 小时）可诱导 TCCSUP 和 MBT-2 细胞的细胞周期停滞和细胞凋亡。Nortriptyline（12.55-100 μM；24 小时）可诱导这些膀胱癌细胞的内在和外在细胞凋亡。viabiltycycleTCCSUP and MBT-2 cells25 μM, 50 μM, or 100 μM (TCCSUP); 12.5 μM, 25 μM, or 50 μM (MBT-2 cells)24 hoursCaused cell cycle arrest in these bladder cancer cells.apoptosisTCCSUP and MBT-2 cells25 μM, 50 μM, or 100 μM (TCCSUP); 12.5 μM, 25 μM, or 50 μM (MBT-2 cells)24 hoursInduced apoptosis in both TCCSUP and MBT-2 cellsTCCSUP and MBT-2 cells25 μM, 50 μM, or 100 μM (TCCSUP); 12.5 μM, 25 μM, or 50 μM (MBT-2 cells)24 hoursIncreased the expression of Fas, FasL, FADD, Bax, Bak, and cleaved forms of caspase-3, caspase-8, caspase-9, and poly(ADP-ribose) polymerase. Decreased the expression of Bcl-2, Bcl-xL, BH3 interacting domain death agonist, X-linked inhibitor of apoptosis protein, and survivin.
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects.N
体内研究：
Nortriptyline（10-20 mg/kg；腹腔注射；每天；持续三周）可抑制接种 MBT-2 细胞的小鼠膀胱肿瘤的生长。Animal Model:Adult male C3H/HeN mice (25-30 g; 2-3 months of age) injected with MBT-2 cells
Dosage:10 or 20 mg/kg
Administration:Intraperitoneal injection; every day; for three weeks.
Result:Suppressed tumor growth in mice inoculated with MBT-2 cells.
体外研究：
Amitriptyline 由 CYP2C19 代谢为活性代谢物 Nortriptyline。Nortriptyline 比血清素更能有效地阻止去甲肾上腺素的再摄取。Nortriptyline（6.25-100 μM；24-72 小时）以浓度和时间依赖性方式显着降低 TCCSUP 和小鼠 MBT-2 膀胱癌细胞的活力。Nortriptyline（12.55-100 μM；24 小时）可诱导 TCCSUP 和 MBT-2 细胞的细胞周期停滞和细胞凋亡。Nortriptyline（12.55-100 μM；24 小时）可诱导这些膀胱癌细胞的内在和外在细胞凋亡。viabiltycycleTCCSUP and MBT-2 cells25 μM, 50 μM, or 100 μM (TCCSUP); 12.5 μM, 25 μM, or 50 μM (MBT-2 cells)24 hoursCaused cell cycle arrest in these bladder cancer cells.apoptosisTCCSUP and MBT-2 cells25 μM, 50 μM, or 100 μM (TCCSUP); 12.5 μM, 25 μM, or 50 μM (MBT-2 cells)24 hoursInduced apoptosis in both TCCSUP and MBT-2 cellsTCCSUP and MBT-2 cells25 μM, 50 μM, or 100 μM (TCCSUP); 12.5 μM, 25 μM, or 50 μM (MBT-2 cells)24 hoursIncreased the expression of Fas, FasL, FADD, Bax, Bak, and cleaved forms of caspase-3, caspase-8, caspase-9, and poly(ADP-ribose) polymerase. Decreased the expression of Bcl-2, Bcl-xL, BH3 interacting domain death agonist, X-linked inhibitor of apoptosis protein, and survivin.
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