产品
编 号：F439360
分子式：C8H15NO3
分子量：173.21
分子式：C8H15NO3
分子量：173.21
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 72741-87-8
产品详情
生物活性：
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.
体内研究：
Swainsonine (1 mg/kg；腹腔注射；每天两次，持续 10 天) 和顺铂提高了小鼠的抗肿瘤功效。Animal Model:Eighty-seven sixty-day-old male C57BL/6 mice
Dosage:1 mg/kg (cisplatin; 0.25 mg/kg, i.p., every other day for 10 days)
Administration:I.p.; twice daily for ten days
Result:Showed a significant reduction in ascites volume of 63.5% was observed in mice and a significant reduction in the percentage of cells in the G0/G1, S and G2 phases.
体外研究：
Swainsonine (0-40 μM；12 h) 在 U251 和 LN444 细胞中显示抗增殖活性。 Swainsonine (30 μM；12 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期，并降低 CyclinD1 和 CDK4 蛋白水平的表达，增加 p16 蛋白水平的表达。 Swainsonine (30 μM；12 h) 减少胶质瘤细胞迁移和侵袭。
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.
体内研究：
Swainsonine (1 mg/kg；腹腔注射；每天两次，持续 10 天) 和顺铂提高了小鼠的抗肿瘤功效。Animal Model:Eighty-seven sixty-day-old male C57BL/6 mice
Dosage:1 mg/kg (cisplatin; 0.25 mg/kg, i.p., every other day for 10 days)
Administration:I.p.; twice daily for ten days
Result:Showed a significant reduction in ascites volume of 63.5% was observed in mice and a significant reduction in the percentage of cells in the G0/G1, S and G2 phases.
体外研究：
Swainsonine (0-40 μM；12 h) 在 U251 和 LN444 细胞中显示抗增殖活性。 Swainsonine (30 μM；12 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期，并降低 CyclinD1 和 CDK4 蛋白水平的表达，增加 p16 蛋白水平的表达。 Swainsonine (30 μM；12 h) 减少胶质瘤细胞迁移和侵袭。
产品资料
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