产品
编 号：F441208
分子式：C11H12N2O2
分子量：204.23
分子式：C11H12N2O2
分子量：204.23
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
结构图
CAS No: 73-22-3
产品详情
生物活性：
L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels.
体内研究：
L-Tryptophan (Tryptophan；10、50 kg/mg/天；腹膜内注射；连续三周) 以 50 mg/kg/天可增强 mBMSC 体内的迁移、集落形成和成骨分化。L-Tryptophan (50 毫克/公斤/天；腹腔注射；连续三周) 加速小鼠股骨手术缺损的骨再生。Animal Model:Five-week-old C57BL/6 mice
Dosage:10, 50 kg/mg
Administration:Intraperitoneally; daily; for consecutive three weeks
Result:The concentration of 50 mg/kg/day induced a significant increase in the number of SSEA-4 positive cells. Increased the mRNA levels of Nanog and Oct-4 and the colony-forming ability of mBMSCs with 50 mg/kg/day.
体外研究：
L-Tryptophan (Tryptophan；500、1000 μM；48 小时) 高剂量下可显着抑制 pTr2 细胞增殖并增加细胞周期 G1 期的细胞百分比。L-Tryptophan (10 μM；持续三周) 增强 hBMSC 的体外迁移、集落形成和成骨分化。L-Tryptophan (10 μM；持续三周) 降低脂肪形成标志物 PPARγ 和 LPL 的 mRNA 水平。
L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels.
体内研究：
L-Tryptophan (Tryptophan；10、50 kg/mg/天；腹膜内注射；连续三周) 以 50 mg/kg/天可增强 mBMSC 体内的迁移、集落形成和成骨分化。L-Tryptophan (50 毫克/公斤/天；腹腔注射；连续三周) 加速小鼠股骨手术缺损的骨再生。Animal Model:Five-week-old C57BL/6 mice
Dosage:10, 50 kg/mg
Administration:Intraperitoneally; daily; for consecutive three weeks
Result:The concentration of 50 mg/kg/day induced a significant increase in the number of SSEA-4 positive cells. Increased the mRNA levels of Nanog and Oct-4 and the colony-forming ability of mBMSCs with 50 mg/kg/day.
体外研究：
L-Tryptophan (Tryptophan；500、1000 μM；48 小时) 高剂量下可显着抑制 pTr2 细胞增殖并增加细胞周期 G1 期的细胞百分比。L-Tryptophan (10 μM；持续三周) 增强 hBMSC 的体外迁移、集落形成和成骨分化。L-Tryptophan (10 μM；持续三周) 降低脂肪形成标志物 PPARγ 和 LPL 的 mRNA 水平。
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