产品
编 号：F445583
分子式：C24H32O7
分子量：432.51
分子式：C24H32O7
分子量：432.51
产品类型
规格
价格
是否有货
5mg
400
In-stock
10mg
560
In-stock
50mg
1400
In-stock
100mg
2100
In-stock
结构图
CAS No: 7432-28-2
产品详情
生物活性：
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats.
体内研究：
Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice.Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats.Animal Model:Male ICR mice (4-weeks) were treated with λ-carrageenan by intraperitoneal injection into the right hind paw
Dosage:100, 200 mg/kg
Administration:A single i.p.
Result:Inhibited paw edema by 33.43 % (100 mg/kg) and 57.38 % (200 mg/kg) at 3 h.
体外研究：
Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells.Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages.Schisandrin inhibits the SK-HEP-1, SNU-638, andT47D cells proliferation, with IC50s of 42.0, 53.1, and 40.0 μM, respectively.Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance.
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats.
体内研究：
Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice.Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats.Animal Model:Male ICR mice (4-weeks) were treated with λ-carrageenan by intraperitoneal injection into the right hind paw
Dosage:100, 200 mg/kg
Administration:A single i.p.
Result:Inhibited paw edema by 33.43 % (100 mg/kg) and 57.38 % (200 mg/kg) at 3 h.
体外研究：
Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells.Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages.Schisandrin inhibits the SK-HEP-1, SNU-638, andT47D cells proliferation, with IC50s of 42.0, 53.1, and 40.0 μM, respectively.Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备