产品
编 号：F446120
分子式：C12H19N3O5S
分子量：317.36
分子式：C12H19N3O5S
分子量：317.36
产品类型
规格
价格
是否有货
25mg
250
In-stock
50mg
355
In-stock
100mg
480
In-stock
250mg
900
In-stock
500mg
1223
In-stock
结构图
CAS No: 74431-23-5
产品详情
生物活性：
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.
体内研究：
Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent.Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single).50Drug and dose(mg/kg)Cmax(mg/liter)Tmax(min)AUCtot(mg ? min/liter)Vz/F(ml/kg)Vss/F (ml/kg)CL/F(ml/min/kg)t1/2(min)MRT(min)
Imipenem
815 (7.1)21 (11)1,470 (777)648 (330)721 (343)6.7 (3)67 (11)108 (12)
1634 (6)28 (18)2,857 (559)507 (140)543 (121)5.8 (1)60 (9.1)94 (10)3254 (11)18 (6.1)4,895 (635)516 (75)566 (83)6.6 (0.8)54 (6.5)86 (11)6469 (37)15 (9.5)6,037 (2,976)547 (274)617 (308)7.4 (3.6)43 (22)70 (35)
Animal Model:Neutropenic mouse model of biofilm lung infection
Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.
体内研究：
Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent.Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single).50Drug and dose(mg/kg)Cmax(mg/liter)Tmax(min)AUCtot(mg ? min/liter)Vz/F(ml/kg)Vss/F (ml/kg)CL/F(ml/min/kg)t1/2(min)MRT(min)
Imipenem
815 (7.1)21 (11)1,470 (777)648 (330)721 (343)6.7 (3)67 (11)108 (12)
1634 (6)28 (18)2,857 (559)507 (140)543 (121)5.8 (1)60 (9.1)94 (10)3254 (11)18 (6.1)4,895 (635)516 (75)566 (83)6.6 (0.8)54 (6.5)86 (11)6469 (37)15 (9.5)6,037 (2,976)547 (274)617 (308)7.4 (3.6)43 (22)70 (35)
Animal Model:Neutropenic mouse model of biofilm lung infection
Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
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