产品
编 号：F447214
分子式：C26H51NO3
分子量：425.69
分子式：C26H51NO3
分子量：425.69
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 74713-59-0
产品详情
生物活性：
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro.
体内研究：
C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice.Animal Model:C57BL/6 mice, with lymphocytic choriomeningitis virus infected
Dosage:0.1 mg/kg
Administration:Intranasal administration
Result:Increased the CD8+ T cell response to influenza in the lungs.
体外研究：
C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.C8-ceramide may increase the endogenous ROS level (10-30 μM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 μM; 24 hours), and consequently triggering the apoptosis (10-50 μM; 48 hours) of NSCLC H1299 cells.
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro.
体内研究：
C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice.Animal Model:C57BL/6 mice, with lymphocytic choriomeningitis virus infected
Dosage:0.1 mg/kg
Administration:Intranasal administration
Result:Increased the CD8+ T cell response to influenza in the lungs.
体外研究：
C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.C8-ceramide may increase the endogenous ROS level (10-30 μM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 μM; 24 hours), and consequently triggering the apoptosis (10-50 μM; 48 hours) of NSCLC H1299 cells.
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