产品
编 号:F447502
分子式:C19H18O6
分子量:342.34
产品类型
结构图
CAS No: 74805-92-8
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产品详情
生物活性:
Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties.
体内研究:
Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury.
体外研究:
Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L).