产品
编 号：F450587
分子式：C11H11Cl2N3O
分子量：272.13
分子式：C11H11Cl2N3O
分子量：272.13
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 75704-24-4
产品详情
生物活性：
(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.
体内研究：
(Rac)-WAY-161503 (3-30 mg/kg；腹腔注射；雄性 C57BL/6J 小鼠) 剂量依赖性地降低运动活动，这种作用被 5-HT2C/2B 拮抗剂 SER-082 所阻断。Animal Model:Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT2C/2B antagonist SER-082.
(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.
体内研究：
(Rac)-WAY-161503 (3-30 mg/kg；腹腔注射；雄性 C57BL/6J 小鼠) 剂量依赖性地降低运动活动，这种作用被 5-HT2C/2B 拮抗剂 SER-082 所阻断。Animal Model:Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT2C/2B antagonist SER-082.
产品资料
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