产品
编 号：F453491
分子式：C29H44ClN5O18P4
分子量：910.03
分子式：C29H44ClN5O18P4
分子量：910.03
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
询价
询价
100mg
询价
询价
250mg
询价
询价
500mg
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询价
结构图
CAS No: 76748-86-2
产品详情
生物活性：
Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection.
体内研究：
Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) tetraphosphate reduces the parasitic burden in the Echinococcus granulosus-infected mice.Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) tetraphosphate reduces the parasitic burden in secondarily infected (cysts) mice.Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) tetraphosphate exhibits a higher exposure in the liver than in the plasma in male ICR mice.Animal Model:Echinococcus granulosus-infected mice model
Dosage:57 mg/kg
Administration:Oral administration, q.d. for 30 days
Result:Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.
体外研究：
Pyronaridine tetraphosphate (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM.
Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection.
体内研究：
Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) tetraphosphate reduces the parasitic burden in the Echinococcus granulosus-infected mice.Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) tetraphosphate reduces the parasitic burden in secondarily infected (cysts) mice.Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) tetraphosphate exhibits a higher exposure in the liver than in the plasma in male ICR mice.Animal Model:Echinococcus granulosus-infected mice model
Dosage:57 mg/kg
Administration:Oral administration, q.d. for 30 days
Result:Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.
体外研究：
Pyronaridine tetraphosphate (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM.
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