产品
编 号：F453648
分子式：C19H15ClNNaO4
分子量：379.77
分子式：C19H15ClNNaO4
分子量：379.77
产品类型
规格
价格
是否有货
结构图
CAS No: 7681-54-1
产品详情
生物活性：
Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research..
体内研究：
Indomethacin (Indometacin) sodium (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia.Indomethacin (Indometacin) sodium (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo.Animal Model:Male Sprague-Dawley rats
Dosage:0.01-10 mg/kg
Administration:Oral administration; for 3 hours
Result:Inhibited the carrageenan-induced rat paw oedema (ED50=2.0?mg/kg) and hyperalgesia (ED50=1.5?mg/kg) in a dose-dependent manner.
Animal Model:Male C57BL/6J mice
Dosage:10 mg/mL
Administration:Oral administration; daily, for 29 days
Result:Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.
体外研究：
Indomethacin (Indometacin) sodium (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro.Indomethacin (Indometacin) sodium (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC50=2μM).
Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research..
体内研究：
Indomethacin (Indometacin) sodium (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia.Indomethacin (Indometacin) sodium (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo.Animal Model:Male Sprague-Dawley rats
Dosage:0.01-10 mg/kg
Administration:Oral administration; for 3 hours
Result:Inhibited the carrageenan-induced rat paw oedema (ED50=2.0?mg/kg) and hyperalgesia (ED50=1.5?mg/kg) in a dose-dependent manner.
Animal Model:Male C57BL/6J mice
Dosage:10 mg/mL
Administration:Oral administration; daily, for 29 days
Result:Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.
体外研究：
Indomethacin (Indometacin) sodium (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro.Indomethacin (Indometacin) sodium (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC50=2μM).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备