产品
编 号：F462657
分子式：C20H17N7O2
分子量：387.39
分子式：C20H17N7O2
分子量：387.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 798577-91-0
产品详情
生物活性：
Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division.
体外研究：
Avanbulin (0-4 μM) binds to tubulin in the site as Colchicine with an apparent Kd value of 244 nM..Avanbulin (50 μM; 0, 10, 20, 30, 60 min) induces the proteolysis of tubulin.Avanbulin (33 nM; 0, 10, 20, 30, 60 min; HeLa-tubGFP cells) collapses the mitotic spindle and forms the tiny tubulin aggregates.Avanbulin does not induce the formation of tubulin oligomers.Avanbulin induces growth inhibition of 23 tumor cell lines with a median relative IC50 of 13.8 nM (96 hours) .Avanbulin (6 nM and 20 nM) inhibits the migration of GBM6 and GBM9 cells.Avanbulin (6 nM and 20 nM; GBM6-shEB1 and GBM6-sh0 cells) triggers astrocytic differentiation of GBM6 in an EB1-dependent manner.Avanbulin (12? nM; 4? h) reduces kinetochore-microtubule (KT–MT) occupancy of MG132(10 μM; 2h) treated hTert-RPE1 eGFP-α-tubulin cells.Avanbulin (12 ?nM; 4 ?h) reduces average inter-KT distances of cells, shows intact spindle morphology, and lacks obvious chromosome alignment defects.
Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division.
体外研究：
Avanbulin (0-4 μM) binds to tubulin in the site as Colchicine with an apparent Kd value of 244 nM..Avanbulin (50 μM; 0, 10, 20, 30, 60 min) induces the proteolysis of tubulin.Avanbulin (33 nM; 0, 10, 20, 30, 60 min; HeLa-tubGFP cells) collapses the mitotic spindle and forms the tiny tubulin aggregates.Avanbulin does not induce the formation of tubulin oligomers.Avanbulin induces growth inhibition of 23 tumor cell lines with a median relative IC50 of 13.8 nM (96 hours) .Avanbulin (6 nM and 20 nM) inhibits the migration of GBM6 and GBM9 cells.Avanbulin (6 nM and 20 nM; GBM6-shEB1 and GBM6-sh0 cells) triggers astrocytic differentiation of GBM6 in an EB1-dependent manner.Avanbulin (12? nM; 4? h) reduces kinetochore-microtubule (KT–MT) occupancy of MG132(10 μM; 2h) treated hTert-RPE1 eGFP-α-tubulin cells.Avanbulin (12 ?nM; 4 ?h) reduces average inter-KT distances of cells, shows intact spindle morphology, and lacks obvious chromosome alignment defects.
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