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编 号：F473796
分子式：C11H11NO
分子量：173.21
分子式：C11H11NO
分子量：173.21
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CAS No: 83-70-5
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生物活性：
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages.
体外研究：
Vitamin K5 (0-1600 μmoL/L) 增强 UVA 辐照对大肠杆菌，蜡样芽孢杆菌， 铜绿假单胞菌， 金黄色葡萄球菌，表皮葡萄球菌和肺炎克雷伯菌的抑菌作用。Vitamin K5 (250-1000 μmoL/L) 产生超氧阴离子自由基和羟基自由基，在 UVA 2.9 J cm-2 的固定剂量下。Vitamin K5 (0-100 μM; 1 h) 剂量依赖性地抑制细胞葡萄糖消耗和乳酸生成。Vitamin K5 剂量依赖性地抑制 colon 26 细胞的增殖。Vitamin K5 诱导细胞凋亡，增加 colon 26 细胞 caspase-3 活性。
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages.
体外研究：
Vitamin K5 (0-1600 μmoL/L) 增强 UVA 辐照对大肠杆菌，蜡样芽孢杆菌， 铜绿假单胞菌， 金黄色葡萄球菌，表皮葡萄球菌和肺炎克雷伯菌的抑菌作用。Vitamin K5 (250-1000 μmoL/L) 产生超氧阴离子自由基和羟基自由基，在 UVA 2.9 J cm-2 的固定剂量下。Vitamin K5 (0-100 μM; 1 h) 剂量依赖性地抑制细胞葡萄糖消耗和乳酸生成。Vitamin K5 剂量依赖性地抑制 colon 26 细胞的增殖。Vitamin K5 诱导细胞凋亡，增加 colon 26 细胞 caspase-3 活性。
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