产品
编 号：F474472
分子式：C17H20N4O6
分子量：376.36
分子式：C17H20N4O6
分子量：376.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
320
In-stock
1g
400
In-stock
5g
640
In-stock
结构图
CAS No: 83-88-5
产品详情
生物活性：
Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction.
体内研究：
Riboflavin (10 mg/kg, 口服, 每日一次) 促进 swiss albino 小鼠的生长。Riboflavin (1-600 mg/kg, 口服, 一次) 在福尔马林、卡拉胶诱导的热痛觉过敏和脊髓神经结扎大鼠模型中具有抗痛觉、抗过敏和抗炎作用。Riboflavin (3-100 mg/kg，腹腔注射，一次) 在乙酸诱导的收缩小鼠模型中以剂量依赖性方式抑制伤害性反应。Riboflavin (6-12 mg/kg，腹腔注射，一次) 可降低甲醛诱导的小鼠模型的第二阶段伤害性反应。Animal Model:Swiss albino mice
Dosage:10 mg/kg
Administration:Oral gavage (p.o.), daily
Result:Increased the growth rate of pregnant and newbron mice.Increased the percent conception and average litter size of pregnant mices.Improved the percent zinc absorption in male mices.Increased the levels of zinc and iron in organs in male and female mices.Increased the percent hemoglobin and the blood zinc value of female mices.
Animal Model:Female Wistar rats
Dosage:1-600 mg/kg
Administration:Oral gavage (p.o.), one time
Result:Reduced flinching behavior during phase 2 in formalin-injected mice by doses of 1-50 mg/kg.Produced a significant antihyperalgesic effect in carrageenan-injected mice by doses of 6.25-150 mg/kg.Reduced carrageenan-induced edema by doses of 50-150 mg/kg.Didn’t reduce tactile allodynia in the spinal nerve ligation model by doses of 150-600 mg/kg.
体外研究：
Riboflavin (5-50 μM, 24 h) 在紫外光照射后对 HL60 细胞具有很强的细胞毒作用，这是由细胞凋亡介导的。Riboflavin (0.76-48.76 nM, 96 h) 以剂量依赖性方式提高HepG2 细胞的活力和谷胱甘肽还原酶活性，并减少细胞凋亡。
Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction.
体内研究：
Riboflavin (10 mg/kg, 口服, 每日一次) 促进 swiss albino 小鼠的生长。Riboflavin (1-600 mg/kg, 口服, 一次) 在福尔马林、卡拉胶诱导的热痛觉过敏和脊髓神经结扎大鼠模型中具有抗痛觉、抗过敏和抗炎作用。Riboflavin (3-100 mg/kg，腹腔注射，一次) 在乙酸诱导的收缩小鼠模型中以剂量依赖性方式抑制伤害性反应。Riboflavin (6-12 mg/kg，腹腔注射，一次) 可降低甲醛诱导的小鼠模型的第二阶段伤害性反应。Animal Model:Swiss albino mice
Dosage:10 mg/kg
Administration:Oral gavage (p.o.), daily
Result:Increased the growth rate of pregnant and newbron mice.Increased the percent conception and average litter size of pregnant mices.Improved the percent zinc absorption in male mices.Increased the levels of zinc and iron in organs in male and female mices.Increased the percent hemoglobin and the blood zinc value of female mices.
Animal Model:Female Wistar rats
Dosage:1-600 mg/kg
Administration:Oral gavage (p.o.), one time
Result:Reduced flinching behavior during phase 2 in formalin-injected mice by doses of 1-50 mg/kg.Produced a significant antihyperalgesic effect in carrageenan-injected mice by doses of 6.25-150 mg/kg.Reduced carrageenan-induced edema by doses of 50-150 mg/kg.Didn’t reduce tactile allodynia in the spinal nerve ligation model by doses of 150-600 mg/kg.
体外研究：
Riboflavin (5-50 μM, 24 h) 在紫外光照射后对 HL60 细胞具有很强的细胞毒作用，这是由细胞凋亡介导的。Riboflavin (0.76-48.76 nM, 96 h) 以剂量依赖性方式提高HepG2 细胞的活力和谷胱甘肽还原酶活性，并减少细胞凋亡。
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