产品
编 号:F475355
分子式:C16H19N7O3
分子量:357.37
产品类型
结构图
CAS No: 842148-40-7
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产品详情
生物活性:
AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.
体内研究:
Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.
体外研究:
The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied.Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.