产品
编 号:F486735
分子式:C72H124N22O21
分子量:1633.89
产品类型
结构图
CAS No: 86555-35-3
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产品详情
生物活性:
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide is also an efficient substrate for PKC with a Km of 16 μM.
体外研究:
The Km values of Malantide are 15 μM and 223 μM for PKA and PKG, respectively. The Vmax values are 23.8 units/mg and 6.6 units/mg for for PKA and PKG, respectively.A statistically significant effect of isoprenaline on the activity ratio of guinea-pig heart was only: observed with Malantide.