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编 号:F486739
分子式:C20H19N5O3S
分子量:409.46
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生物活性:
TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively.

体外研究:
TC-E 5001 inhibits TNKS2, with an IC50 of 33 nM.
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