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编 号：F490243
分子式：C27H36BN3O7
分子量：525.4
分子式：C27H36BN3O7
分子量：525.4
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CAS No: 871576-03-3
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生物活性：
Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.
体内研究：
Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs.Animal Model:Chicks
Dosage:1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes.2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes.5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes.
Administration:Bolus plus infusion
Result:Elevated PD markers, and produced minimal post-operative blood loss.
Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.
体内研究：
Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs.Animal Model:Chicks
Dosage:1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes.2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes.5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes.
Administration:Bolus plus infusion
Result:Elevated PD markers, and produced minimal post-operative blood loss.
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