产品
编 号：F492418
分子式：C21H28Cl2N6O2
分子量：467.39
分子式：C21H28Cl2N6O2
分子量：467.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 875320-31-3
产品详情
生物活性：
Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity.
体内研究：
JNJ-26481585 (40 mg/kg; p.o.; once daily, for 3 days) as a potent HDAC1 inhibitor p21waf1,cip1 ZsGreen tumors in vivo.JNJ-26481585 induces continuous H3 acetylation in tumor tissue in vivo.JNJ-26481585 (10 mg/kg; once daily; i.p.; for 14 days) strongly inhibits the growth of large pre-established HCT116 colon xenografts.Animal Model:NMRI nude mice, with HCT116 colon carcinoma cells xenografts
Dosage:10 mg/kg
Administration:Intraperitoneal injection, once daily, for 14 days
Result:Strongly inhibited the growth of large pre-established HCT116 colon xenografts.
体外研究：
JNJ-26481585 inhibits HDAC isozymes in vitro.JNJ-26481585 (30-1000 nM; 24 hours) is a potent pan-HDAC inhibitor in tumor cells.JNJ-26481585 has broad spectrum antiproliferative activity against solid and hematologic cancer cell lines and induces apoptosis.
Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity.
体内研究：
JNJ-26481585 (40 mg/kg; p.o.; once daily, for 3 days) as a potent HDAC1 inhibitor p21waf1,cip1 ZsGreen tumors in vivo.JNJ-26481585 induces continuous H3 acetylation in tumor tissue in vivo.JNJ-26481585 (10 mg/kg; once daily; i.p.; for 14 days) strongly inhibits the growth of large pre-established HCT116 colon xenografts.Animal Model:NMRI nude mice, with HCT116 colon carcinoma cells xenografts
Dosage:10 mg/kg
Administration:Intraperitoneal injection, once daily, for 14 days
Result:Strongly inhibited the growth of large pre-established HCT116 colon xenografts.
体外研究：
JNJ-26481585 inhibits HDAC isozymes in vitro.JNJ-26481585 (30-1000 nM; 24 hours) is a potent pan-HDAC inhibitor in tumor cells.JNJ-26481585 has broad spectrum antiproliferative activity against solid and hematologic cancer cell lines and induces apoptosis.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备