产品
编 号：F058624
分子式：C22H29N3O4S
分子量：431.55
分子式：C22H29N3O4S
分子量：431.55
产品类型
规格
价格
是否有货
25mg
400
In-stock
50mg
640
In-stock
100mg
960
In-stock
结构图
CAS No: 118288-08-7
产品详情
生物活性：
Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease.
体内研究：
Lafutidine (3-30 mg/kg; p.o.; twice daily; for 6 days) dose-dependently reduces the severity of dextran sulfate Na (DSS)-induced colitis and significantly mitigates changes in the colon length and myeloperoxidase (MPO) activity.Animal Model:Male Wistar rats (180-200 g)
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Oral administration, twice daily, for 6 days
Result:Reduced the severity of DSS-induced ulcerative colitis in a dose-dependent manner.
体外研究：
Lafutidine exhibits gastric mucosal protective action mediated by capsaicin-sensitive afferent neurons, in addition to a potent antisecretory effect.Lafutidine (0.1-10 μM) significantly augments the periarterial nerve stimulation (PNS, 1 Hz) induced-vasodilation in a concentration-dependent manner in rat perfused mesenteric vascular beds.
Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease.
体内研究：
Lafutidine (3-30 mg/kg; p.o.; twice daily; for 6 days) dose-dependently reduces the severity of dextran sulfate Na (DSS)-induced colitis and significantly mitigates changes in the colon length and myeloperoxidase (MPO) activity.Animal Model:Male Wistar rats (180-200 g)
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Oral administration, twice daily, for 6 days
Result:Reduced the severity of DSS-induced ulcerative colitis in a dose-dependent manner.
体外研究：
Lafutidine exhibits gastric mucosal protective action mediated by capsaicin-sensitive afferent neurons, in addition to a potent antisecretory effect.Lafutidine (0.1-10 μM) significantly augments the periarterial nerve stimulation (PNS, 1 Hz) induced-vasodilation in a concentration-dependent manner in rat perfused mesenteric vascular beds.
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