产品
编 号：F058656
分子式：C19H17NO2S
分子量：323.41
分子式：C19H17NO2S
分子量：323.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
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询价
结构图
CAS No: 118292-41-4
产品详情
生物活性：
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
体内研究：
Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats.MaleFemale Male
Dose (mg kg-1)4.44.40.49
AUC (μg h mL-1)9.31 (2.14)9.78 (1.36)0.594 (0.95)
CL (mL min-1 kg-1)7.96 (1.59)7.62 (0.85)14.0 (2.2)
k (h-1)0.562 (0.339)0.820 (0.146) 0.741 (0.115)
T1/2 (h)1.64 (0.92)0.86 (0.14)0.95 (0.16)
V0 (L kg-1)0.43 (0.05)0.49 (0.06)1.31 (1.15)
Vβ (L kg-1)--1.14 (0.09)
Vmax (μg min-1)9.08 (2.89)6.09 (1.22)-
Km (μg mL-1)7.09 (1.35)5.12 (1.19)-
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
体内研究：
Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats.MaleFemale Male
Dose (mg kg-1)4.44.40.49
AUC (μg h mL-1)9.31 (2.14)9.78 (1.36)0.594 (0.95)
CL (mL min-1 kg-1)7.96 (1.59)7.62 (0.85)14.0 (2.2)
k (h-1)0.562 (0.339)0.820 (0.146) 0.741 (0.115)
T1/2 (h)1.64 (0.92)0.86 (0.14)0.95 (0.16)
V0 (L kg-1)0.43 (0.05)0.49 (0.06)1.31 (1.15)
Vβ (L kg-1)--1.14 (0.09)
Vmax (μg min-1)9.08 (2.89)6.09 (1.22)-
Km (μg mL-1)7.09 (1.35)5.12 (1.19)-
产品资料
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