产品
编 号：F059199
分子式：C10H5N3O3
分子量：215.17
分子式：C10H5N3O3
分子量：215.17
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 118409-62-4
产品详情
生物活性：
AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research.
体内研究：
AG 126 (intraperitoneal injection; 1-10 mg/kg; 1 h and 6 h after Zymosan treatment) treatment attenuates the degree of multiple organ failure (MOF) associated with Zymosan-induced peritonitis in the rat.Animal Model:Male Sprague-Dawley rats treated with Zymosan (500 mg/kg)
Dosage:10 mg/kg, 3 mg/kg or 1 mg/kg
Administration:Intraperitoneal injection; 10, 3, or 1 mg/kg; 1 h and 6 h after Zymosan treatment
Result:Attenuated the peritoneal exudation and the migration of polymorphonuclear cells caused by Zymosan in a dose-dependent fashion.Attenuated the lung, liver, and intestinal injury.Reduced the production of peroxynitrite and of pro-inflammatory cytokines TNF-alpha and IL-1beta.
体外研究：
AG126 (10 μM; overnight) increases the viability of ARPE-19 cells.AG126 at concentrations higher than 10 μM show toxic to ARPE-19 cells and can enhance H2O2 toxicity.AG126 (0.1-100 μM) inhibits VEGF-induced proliferation of BRMECs.
AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research.
体内研究：
AG 126 (intraperitoneal injection; 1-10 mg/kg; 1 h and 6 h after Zymosan treatment) treatment attenuates the degree of multiple organ failure (MOF) associated with Zymosan-induced peritonitis in the rat.Animal Model:Male Sprague-Dawley rats treated with Zymosan (500 mg/kg)
Dosage:10 mg/kg, 3 mg/kg or 1 mg/kg
Administration:Intraperitoneal injection; 10, 3, or 1 mg/kg; 1 h and 6 h after Zymosan treatment
Result:Attenuated the peritoneal exudation and the migration of polymorphonuclear cells caused by Zymosan in a dose-dependent fashion.Attenuated the lung, liver, and intestinal injury.Reduced the production of peroxynitrite and of pro-inflammatory cytokines TNF-alpha and IL-1beta.
体外研究：
AG126 (10 μM; overnight) increases the viability of ARPE-19 cells.AG126 at concentrations higher than 10 μM show toxic to ARPE-19 cells and can enhance H2O2 toxicity.AG126 (0.1-100 μM) inhibits VEGF-induced proliferation of BRMECs.
产品资料
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