产品
编 号：F512025
分子式：C20H19N3O3
分子量：349.38
分子式：C20H19N3O3
分子量：349.38
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 902128-92-1
产品详情
生物活性：
E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent.
体内研究：
E7016 has antitumor efficacy in murine xenograft studies.Administration of E7016 (40 mg/kg; oral gavage) to mice bearing U251 xenografts enhances the effectiveness of the Temozolomide/radiation combination. Mice treated with E7016/irradiation/Temozolomide have an additional growth delay of six days compared with the combination of Temozolomide and irradiation in vivo.Animal Model:Four- to six-week-old female nude mice
Dosage:40 mg/kg
Administration:Oral gavage
Result:E7016 enhanced the radiation/Temozolomide (3 mg/kg orally)-induced tumor growth delay of U251 xenografts.
体外研究：
E7016 can enhance tumor cell radiosensitivity through the inhibition of DNA repair.E7016 (3 μM)-mediated radiosensitization occurs through an increase in the number of cells undergoing mitotic catastrophe and not an increase in the number of cells undergoing apoptosis.E7016 inhibits PARP by mimicking NAD+.
E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent.
体内研究：
E7016 has antitumor efficacy in murine xenograft studies.Administration of E7016 (40 mg/kg; oral gavage) to mice bearing U251 xenografts enhances the effectiveness of the Temozolomide/radiation combination. Mice treated with E7016/irradiation/Temozolomide have an additional growth delay of six days compared with the combination of Temozolomide and irradiation in vivo.Animal Model:Four- to six-week-old female nude mice
Dosage:40 mg/kg
Administration:Oral gavage
Result:E7016 enhanced the radiation/Temozolomide (3 mg/kg orally)-induced tumor growth delay of U251 xenografts.
体外研究：
E7016 can enhance tumor cell radiosensitivity through the inhibition of DNA repair.E7016 (3 μM)-mediated radiosensitization occurs through an increase in the number of cells undergoing mitotic catastrophe and not an increase in the number of cells undergoing apoptosis.E7016 inhibits PARP by mimicking NAD+.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备