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编 号：F062933
分子式：C145H234N52O44S3
分子量：3505.96
分子式：C145H234N52O44S3
分子量：3505.96
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CAS No: 118812-69-4
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生物活性：
Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.
体内研究：
Ularitide (10?nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs.Animal Model:Female dogs with or without surgically induced chronic aortocaval fistula
Dosage:5 and 10 pmol/kg/min
Administration:i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min.
Result:Increased in urine volume and sodium excretion with high-output CHF.
体外研究：
Ularitide increases the amount of cyclic nucleotides and decreases the raise in permeability in HUVEC cells.Ularitide (1 nM-1 μM, 15 min) reverses methacholine-evoked contraction in bovine bronchi.Ularitide (1 μM, 0-300 s) increases cyclic GMP levels in the presence of phosphoramidon in bovine bronchi.
Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.
体内研究：
Ularitide (10?nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs.Animal Model:Female dogs with or without surgically induced chronic aortocaval fistula
Dosage:5 and 10 pmol/kg/min
Administration:i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min.
Result:Increased in urine volume and sodium excretion with high-output CHF.
体外研究：
Ularitide increases the amount of cyclic nucleotides and decreases the raise in permeability in HUVEC cells.Ularitide (1 nM-1 μM, 15 min) reverses methacholine-evoked contraction in bovine bronchi.Ularitide (1 μM, 0-300 s) increases cyclic GMP levels in the presence of phosphoramidon in bovine bronchi.
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