产品
编 号：F599939
分子式：C10H14N5NaO3
分子量：275.24
分子式：C10H14N5NaO3
分子量：275.24
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CAS No: 97845-62-0
产品详情
生物活性：
Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 μg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse.
体内研究：
Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse.Animal Model:Three-week-old female Balb/c mice
Dosage:100 mg/kg
Administration:S.c.; daily for 5 days
Result:Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
体外研究：
Penciclovir sodium (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively.Penciclovir sodium (0-100 μg/ml) shows no-toxic to uninfected human cells.
Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 μg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse.
体内研究：
Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse.Animal Model:Three-week-old female Balb/c mice
Dosage:100 mg/kg
Administration:S.c.; daily for 5 days
Result:Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
体外研究：
Penciclovir sodium (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively.Penciclovir sodium (0-100 μg/ml) shows no-toxic to uninfected human cells.
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