产品
编 号:F601577
分子式:C22H21ClN4O5
分子量:456.88
产品类型
结构图
CAS No: 2331255-53-7
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产品详情
生物活性:
ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). ABC99 preserves Wnt3A signaling in the presence of NOTUM.
体外研究:
ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner.ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner.