产品
编 号：F605982
分子式：C27H30O6
分子量：450.52
分子式：C27H30O6
分子量：450.52
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 65893-94-9
产品详情
生物活性：
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells.
体内研究：
Animal Model:Female NOD/SCID mice (ASZ001 BCC allografts)
Dosage:100 μmol/kg
Administration:I.p.; every second day for 18 days
Result:A significant reduction of tumor growth as well as Gli1 mRNA levels was observed.
体外研究：
Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma.Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels.
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells.
体内研究：
Animal Model:Female NOD/SCID mice (ASZ001 BCC allografts)
Dosage:100 μmol/kg
Administration:I.p.; every second day for 18 days
Result:A significant reduction of tumor growth as well as Gli1 mRNA levels was observed.
体外研究：
Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma.Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels.
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