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编 号：F609591
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是否有货
5mg
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10mg
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25mg
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50mg
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100mg
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CAS No: 936541-36-5
产品详情
生物活性：
Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities.
体内研究：
Lactoferrin (重组人乳铁蛋白) (1,000 mg/kg，口服灌胃，每天两次，持续 8 天) 可抑制 80% 的 T 细胞免疫功能低下的 nu/nu 小鼠鳞状细胞癌 (O12) 肿瘤的生长 。Lactoferrin (牛乳铁蛋白) (100 和 200 mg/kg，口服灌胃，连续 30 天) 对败血症诱发的急性肺损伤大鼠模型显示出保护作用。Animal Model:Squamous cell carcinoma model (O12 cell injected into the left flank of nu/numice)
Dosage:1,000 mg/kg
Administration:oral gavage, twice daily for 8 days
Result:Inhibited the tumor growth by 80%.
Animal Model:Sepsis-induced acute lung injury rat model
Dosage:100 and 200 mg/kg
Administration:oral gavage,for 30 consecutive days
Result:Reduced the wet/dry ratio of lung tissue by 30.7% and 61.3%, and lipid peroxidation by 22.3% and 67%, at concentrations of 100 and 200mg/kg.Reduced Inflammatory markers, neutrophils, lymphocytes and total cell count.Reduced MPO activity.
体外研究：
Lactoferrin (0-1 000 μg/mL，7 天) 以剂量依赖性方式抑制上皮细胞 (HaCaT) 生长。Lactoferrin (500 μg/mL，12 天) 抑制 HaCaT 细胞集落的扩散和生长。Lactoferrin (人或牛乳铁蛋白，1.41 μM 和 0.12 μM）可抑制 Vero 细胞中的 HSV-1 感染达 50%。
Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities.
体内研究：
Lactoferrin (重组人乳铁蛋白) (1,000 mg/kg，口服灌胃，每天两次，持续 8 天) 可抑制 80% 的 T 细胞免疫功能低下的 nu/nu 小鼠鳞状细胞癌 (O12) 肿瘤的生长 。Lactoferrin (牛乳铁蛋白) (100 和 200 mg/kg，口服灌胃，连续 30 天) 对败血症诱发的急性肺损伤大鼠模型显示出保护作用。Animal Model:Squamous cell carcinoma model (O12 cell injected into the left flank of nu/numice)
Dosage:1,000 mg/kg
Administration:oral gavage, twice daily for 8 days
Result:Inhibited the tumor growth by 80%.
Animal Model:Sepsis-induced acute lung injury rat model
Dosage:100 and 200 mg/kg
Administration:oral gavage,for 30 consecutive days
Result:Reduced the wet/dry ratio of lung tissue by 30.7% and 61.3%, and lipid peroxidation by 22.3% and 67%, at concentrations of 100 and 200mg/kg.Reduced Inflammatory markers, neutrophils, lymphocytes and total cell count.Reduced MPO activity.
体外研究：
Lactoferrin (0-1 000 μg/mL，7 天) 以剂量依赖性方式抑制上皮细胞 (HaCaT) 生长。Lactoferrin (500 μg/mL，12 天) 抑制 HaCaT 细胞集落的扩散和生长。Lactoferrin (人或牛乳铁蛋白，1.41 μM 和 0.12 μM）可抑制 Vero 细胞中的 HSV-1 感染达 50%。
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