产品
编 号：F615764
分子式：C44H58IN13O10S
分子量：1087.98
分子式：C44H58IN13O10S
分子量：1087.98
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CAS No: 159600-82-5
产品详情
生物活性：
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.
体内研究：
(p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-inducedexcessive grooming behavior in rats.Animal Model:Male Wistar rats (150 g)
Dosage:1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not
Administration:Intracerebroventricular injection; one week prior to the experiment
Result:Didn’t induce excessive grooming behavior by single dose.Inhibited the induction of excessive grooming behavior by a-MSH.
体外研究：
(p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, humanmelanocortin MC4 or ovine melanocortin MC5 receptor.[Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10).
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.
体内研究：
(p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-inducedexcessive grooming behavior in rats.Animal Model:Male Wistar rats (150 g)
Dosage:1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not
Administration:Intracerebroventricular injection; one week prior to the experiment
Result:Didn’t induce excessive grooming behavior by single dose.Inhibited the induction of excessive grooming behavior by a-MSH.
体外研究：
(p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, humanmelanocortin MC4 or ovine melanocortin MC5 receptor.[Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10).
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