产品
编 号：F618129
分子式：C27H21ClFN3O2
分子量：473.93
分子式：C27H21ClFN3O2
分子量：473.93
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2471978-97-7
产品详情
生物活性：
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels.
体内研究：
BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus.BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po. Animal Model:Intact female rats
Dosage:4.5, 9, 18, 36, 72 mg/kg
Administration:Oral; for 8 days
Result:Dosedependently lowered serum estradiol levels in proestrus.
Animal Model:Female and male Wistar rats
Dosage:0.5 mg/kg of iv or 2 mg/kg of po
Administration:Iv or po
Result:Has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po.
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels.
体内研究：
BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus.BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po. Animal Model:Intact female rats
Dosage:4.5, 9, 18, 36, 72 mg/kg
Administration:Oral; for 8 days
Result:Dosedependently lowered serum estradiol levels in proestrus.
Animal Model:Female and male Wistar rats
Dosage:0.5 mg/kg of iv or 2 mg/kg of po
Administration:Iv or po
Result:Has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po.
产品资料
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