产品
编 号：F618200
分子式：C40H44F2N7O9P
分子量：835.79
分子式：C40H44F2N7O9P
分子量：835.79
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1mg
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CAS No: 2429877-30-3
产品详情
生物活性：
SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.
体外研究：
SI-109 exerts a moderate growth inhibitory activity in MOLM-16 cells (IC50=3 μM).SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM.
SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.
体外研究：
SI-109 exerts a moderate growth inhibitory activity in MOLM-16 cells (IC50=3 μM).SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM.
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