产品
编 号：F648077
分子式：C21H29N3O2
分子量：355.47
分子式：C21H29N3O2
分子量：355.47
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1262395-13-0
产品详情
生物活性：
NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity.
体内研究：
NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer.Animal Model:Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts.
Dosage:80 mg/kg.
Administration:Orally, once daily for 12 days.
Result:Clearly reduced the tumor growth (maximal tumor growth inhibition observed: 48%, maximum body weight loss: 6%).
NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity.
体内研究：
NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer.Animal Model:Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts.
Dosage:80 mg/kg.
Administration:Orally, once daily for 12 days.
Result:Clearly reduced the tumor growth (maximal tumor growth inhibition observed: 48%, maximum body weight loss: 6%).
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