产品
编 号：F712821
分子式：C20H13F9N2O3
分子量：500.31
分子式：C20H13F9N2O3
分子量：500.31
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1928724-23-5
产品详情
生物活性：
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity.
体内研究：
SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity.Animal Model:ARE-Luc mice
Dosage:50 mg/kg
Administration:Subcutaneously; 24 hours
Result:Inhibited AR transcriptional activity.
体外研究：
In LNCaPAR+?cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells.?Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50?of approximately 5 μM for SK33.
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity.
体内研究：
SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity.Animal Model:ARE-Luc mice
Dosage:50 mg/kg
Administration:Subcutaneously; 24 hours
Result:Inhibited AR transcriptional activity.
体外研究：
In LNCaPAR+?cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells.?Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50?of approximately 5 μM for SK33.
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