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编 号：F068882
分子式：C31H35F3N8O3
分子量：624.66
分子式：C31H35F3N8O3
分子量：624.66
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CAS No: 1202884-94-3
产品详情
生物活性：
PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer.
体内研究：
PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in MDA361 tumor bearing nude mice demonstrated by biomarker studies.PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) shows good antitumor efficacy in MDA361 tumor xenograft nude mice model.PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h.Animal Model:MDA361 tumor xenograft nude mice model
Dosage:50, 25, 10 mg/kg
Administration:i.v., once daily for 5 days weekly (2 rounds)
Result:Exhibited significant tumor regression in 50 mg/kg and no tumor regrowth until day 32.Exhibited tumor growth inhibition in 25 and 10 mg/kg.
体外研究：
PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of PI3K-IN-22 相关抗体:
PI3K-IN-22 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer.
体内研究：
PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in MDA361 tumor bearing nude mice demonstrated by biomarker studies.PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) shows good antitumor efficacy in MDA361 tumor xenograft nude mice model.PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h.Animal Model:MDA361 tumor xenograft nude mice model
Dosage:50, 25, 10 mg/kg
Administration:i.v., once daily for 5 days weekly (2 rounds)
Result:Exhibited significant tumor regression in 50 mg/kg and no tumor regrowth until day 32.Exhibited tumor growth inhibition in 25 and 10 mg/kg.
体外研究：
PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of PI3K-IN-22 相关抗体:
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